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Do penile haemodynamics change in the presence of hydrogen sulphide (H 2 S) donor in metabolic syndrome‐induced erectile dysfunction?
Author(s) -
Dayar E.,
Kara E.,
YetikAnacak G.,
Hocaoglu N.,
Bozkurt O.,
Gidener S.,
Durmus N.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12885
Subject(s) - erectile dysfunction , medicine , mean arterial pressure , metabolic syndrome , hemodynamics , blood pressure , endocrinology , intracavernous injection , waist , body mass index , diabetes mellitus , heart rate
Summary Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H 2 S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H 2 S on metS‐induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high‐fructose diet for 10 weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index. Penile hemodynamic parameters were evaluated by the measurement of intracavernous pressure/mean arterial pressure ratio during cavernous nerve stimulation in the presence and absence of intracavernous injection of NaHS (100 μg/50 μl) and its control 0.9%NaCl (50 μl) in both groups. H 2 S levels were measured in penile tissues by methylene blue assay. H 2 S levels were significantly decreased in the penile tissues of the metS group. Decreased intracavernous pressure/mean arterial pressure ratio improved after intracavernous administration of NaHS in the metS group. These results suggest the significant role of H 2 S in the metS‐induced erectile dysfunction that could be a new therapeutic target.