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Paternal age as an independent factor does not affect embryo quality and pregnancy outcomes of testicular sperm extraction‐intracytoplasmic sperm injection in azoospermia
Author(s) -
Park Y. S.,
Lee S. H.,
Lim C. K.,
Choi H. W.,
An J. H.,
Park C. W.,
Lee H. S.,
Lee J. S.,
Seo J. T.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12864
Subject(s) - intracytoplasmic sperm injection , testicular sperm extraction , azoospermia , pregnancy , medicine , gynecology , embryo quality , sperm , pregnancy rate , andrology , obstetrics , advanced maternal age , in vitro fertilisation , infertility , biology , fetus , genetics
Summary This study was performed to evaluate the independent influence of paternal age affecting embryo development and pregnancy using testicular sperm extraction ( TESE )‐intracytoplasmic sperm injection ( ICSI ) in obstructive azoospermia ( OA ) and nonobstructive azoospermia ( NOA ). Paternal patients were divided into the following groups: ≤30 years, 31–35 years, 36–40 years, 41–45 years and ≥46 years. There were no differences in the rates of fertilisation or embryo quality according to paternal and maternal age. However, clinical pregnancy and implantation rates were significantly lower between those ≥46 years of paternal age compared with other age groups. Fertilisation rate was higher in the OA than the NOA , while embryo quality, pregnancy and delivery results were similar. Clinical pregnancy and implantation rates were significantly lower for patients ≥46 years of paternal age compared with younger age groups. In conclusion, fertilisation using TESE in azoospermia was not affected by the independent influence of paternal age; however, as maternal age increased concomitantly with paternal age, rates of pregnancy and delivery differed between those with paternal age <41 years and ≥46 years. Therefore, paternal age ≥46 years old should be considered when applying TESE ‐ ICSI in cases of azoospermia, and patients should be advised of the associated low pregnancy rates.