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NGF promotes mitochondrial function by activating PGC ‐1α in TM 4 Sertoli cells
Author(s) -
Jiang Y. W.,
Zhao Y.,
Chen S. X.,
Chen L.,
Li C. J.,
Zhou X.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12837
Subject(s) - sertoli cell , paracrine signalling , autocrine signalling , mitochondrial biogenesis , nerve growth factor , coactivator , biology , mitochondrion , microbiology and biotechnology , endocrinology , medicine , receptor , spermatogenesis , transcription factor , genetics , gene
Summary Nerve growth factor ( NGF ), which is required for the survival and differentiation of the nervous system, has been proved to play important roles in male reproductive physiology. Several studies have focused on the roles of NGF in the testes. However, no study has reported on the mechanism of paracrine and autocrine actions of NGF in Sertoli cells. This study showed that NGF stimulated mitochondrial activity and biogenesis in TM 4 Sertoli cells. Moreover, our results demonstrated that peroxisome proliferator‐activated receptor‐gamma coactivator‐1α is a possible downstream key target of the NGF signalling pathway. In a 3‐nitropropionic acid cell model, NGF treatment attenuated mitochondrial activity defect and depolarisation. This NGF ‐triggered signalling may help in discovering new therapeutic targets for certain male infertility disorders.