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The presence of human papillomavirus in semen does not affect the integrity of sperm DNA
Author(s) -
CortésGutiérrez E. I.,
DávilaRodríguez M. I.,
Fernández J. L.,
OPérez L. O.,
GarzaFlores M. E.,
Eguren–Garza R.,
Gosálvez J.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12774
Subject(s) - semen , dna fragmentation , sperm , andrology , biology , male infertility , infertility , semen analysis , virology , genetics , medicine , pregnancy , apoptosis , programmed cell death
Summary It remains unknown whether human papillomaviruses ( HPV s) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen samples of 22 normozoospermic patients undergoing infertility treatment, nine fertile donors and seven fertile men with a risk of HPV infection (genital warts or condylomas) were included in the study. The samples were examined by an INNO ‐Li PA test PCR ‐based reverse hybridisation array that identifies 28 types of HPV s as simple or multiple infections. Sperm DNA integrity was determined by sperm chromatin dispersion assay ( SCD ). Our preliminary findings demonstrate an increase in HPV infection in infertile men with respect to fertile men. However, the sperm DNA fragmentation index was not increased in semen containing these viruses.