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Evaluation of serum level of Osteocalcin hormone in male infertility
Author(s) -
ElKamshoushi A. A. M.,
Hassan E. M.,
Hassaan P. S.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12755
Subject(s) - osteocalcin , testosterone (patch) , medicine , endocrinology , semen , hormone , sperm , infertility , endocrine system , male infertility , follicle stimulating hormone , semen analysis , sperm motility , biology , andrology , luteinizing hormone , pregnancy , alkaline phosphatase , biochemistry , genetics , enzyme
Summary The suggested concept of “bone as an endocrine organ” had shed the light on the role of osteocalcin, an osteoblast secreted hormone, in regulation of testosterone production. This study aimed to assess the association between the active undercarboxylated form of osteocalcin (uc OC ) and semen parameters and hormonal levels in infertile male patients. The study was carried on 34 infertile male patients and 20 fertile healthy control males. Semen analysis and serum level of testosterone, LH and FSH were performed in addition to serum level of uc OC in cases and controls. The results revealed significant differences between cases and controls in all measured semen and hormonal parameters. In addition, significant higher level of uc OC in cases than control group ( p = .019). On the other hand, uc OC was not related significantly to any of the measured hormones or semen parameters. There was no significant correlation between uc OC and sperm concentration, total motility, morphology ( p = .594, .640, .940 respectively) and similarly between uc OC and testosterone level or LH level ( p = .275, .954 respectively). The significant higher level of uc OC in infertile cases cannot be used as a predictor of male reproductive parameters.