Premium
Hypoadiponectinemia, elevated iron and high‐sensitivity C‐reactive protein levels and their relation with prostate size in benign prostatic hyperplasia
Author(s) -
Nandeesha H.,
Eldhose A.,
Dorairajan L. N.,
Anandhi B.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12715
Subject(s) - adiponectin , prostate , hyperplasia , medicine , urology , c reactive protein , endocrinology , gastroenterology , inflammation , obesity , insulin resistance , cancer
Summary Elevated iron, high‐sensitivity C‐reactive protein ( CRP ) and hypoadiponectinemia are known to initiate tumour development. There is paucity of data regarding the above‐mentioned parameters and their relation with prostate size in benign prostatic hyperplasia ( BPH ). The present study was designed to assess the levels of iron, hs‐ CRP and adiponectin levels and their association with prostate size in BPH patients. A total of 37 BPH cases and 36 controls were enrolled in the study. Iron, hs‐ CRP and adiponectin were estimated in both the groups. Iron and hs‐ CRP were significantly increased and adiponectin was significantly reduced in BPH cases when compared with controls. Iron (r = .397, p = .015), hs‐ CRP (r = .341, p = .039) and adiponectin (r = −.464, p = .004) were significantly associated with prostate size in BPH cases. Multivariate linear regression analysis showed that iron acts as predictor of prostate size in BPH (R 2 = 0.395, β = 0.526, p = .001). We conclude that iron and hs‐ CRP are elevated and adiponectin is reduced in BPH cases and associated with prostate size.