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eNOS gene T786C , G894T and 4a4b polymorphisms and male infertility susceptibility: a meta‐analysis
Author(s) -
Chang J.,
Pan F.,
Tang Q.,
Wu W.,
Chen M.,
Lu C.,
Ding H.,
Hu L.,
Chen D.,
Xia Y.,
Wang X.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12646
Subject(s) - male infertility , asthenozoospermia , infertility , odds ratio , confidence interval , meta analysis , enos , medicine , azoospermia , semen analysis , gynecology , subgroup analysis , case control study , biology , genetics , pregnancy , nitric oxide synthase , nitric oxide
Summary The association between polymorphism of eNOS and male infertility in several studies was controversial. To explore a more precise estimation of the association, a meta‐analysis of eight case–control studies, including 1,968 cases and 1,539 controls, were selected. The meta‐analysis was conducted by calculating the pooled odds ratio (OR) with a 95% confidence interval (95% CI). Overall, the association between T786C and risk of male infertility was obvious (TC vs. TT: OR, 1.20; 95% CI, 1.01–1.42; CC vs. TT: OR, 3.37; 95% CI, 1.65–6.87; TC/CC vs. TT: OR, 1.47; 95% CI, 1.25–1.73; CC vs. TT/TC: OR, 3.18; 95% CI, 1.54–6.56; TC vs. TT: OR, 1.65; 95% CI, 1.27–2.03). However, no overall association was observed between the other two polymorphisms of eNOS ( G894T and 4a4b ) and male infertility. Stratified analysis showed that significantly strong association between T786C polymorphism and semen quality was present in all three types of male infertility (azoospermia, oligozoospermia and asthenozoospermia). In the subgroup analysis based on ethnicity, both T786C and 4a4b could influence the risk of male infertility in Asian and Caucasian. Further studies of polymorphisms of eNOS with their biological functions are needed to understand the role in the development of male infertility.