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Effects of two‐year testosterone replacement therapy on cognition, emotions and quality of life in young and middle‐aged hypogonadal men
Author(s) -
Lašaitė L.,
Čeponis J.,
Preikša R. T.,
Žilaitienė B.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12633
Subject(s) - psychomotor learning , quality of life (healthcare) , cognition , memory span , testosterone replacement , psychology , audiology , mood , testosterone (patch) , wechsler adult intelligence scale , effects of sleep deprivation on cognitive performance , digit symbol substitution test , medicine , clinical psychology , developmental psychology , psychiatry , working memory , alternative medicine , pathology , hormone , androgen , psychotherapist , placebo
Summary The aim of the study was to examine the effects of two‐year testosterone replacement therapy on cognitive functioning, emotional state and quality of life in young and middle‐aged men with hypogonadotropic hypogonadism. Nineteen males diagnosed with hypogonadotropic hypogonadism participated in the study. Cognitive functions were assessed by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. Emotional state was evaluated by Profile of Mood States. Quality of life was evaluated by WHO Brief Quality of Life Questionnaire. Changes after two‐year testosterone replacement therapy were detected in Trail Making A (42.9 ± 22.3 vs. 36.2 ± 22.5, p = .050) and B (90.6 ± 55.3 vs. 65.6 ± 21.4, p = .025) tests, showing improvement in attention and visual scanning abilities, executive function and psychomotor speed, as well as in Digit Span Test forward score (5.4 ± 2.0 vs. 6.1 ± 2.6, p = .046), showing improvement in attention capacity and psychomotor speed. No significant differences were observed in emotional state and quality of life. In conclusion, beneficial effect in cognitive functioning (improved attention and visual scanning ability, executive function and psychomotor speed), but not in emotional state and quality of life, was observed in young and middle‐aged hypogonadal men after two‐year testosterone replacement therapy.