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Testosterone replacement therapy improves health‐related quality of life for patients with late‐onset hypogonadism: a meta‐analysis of randomized controlled trials
Author(s) -
Nian Y.,
Ding M.,
Hu S.,
He H.,
Cheng S.,
Yi L.,
Li Y.,
Wang Y.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12630
Subject(s) - testosterone replacement , randomized controlled trial , testosterone (patch) , medicine , quality of life (healthcare) , meta analysis , hormone replacement therapy (female to male) , androgen , nursing , hormone
Summary Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late‐onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta‐analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed‐effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health‐related quality of life in terms of the decrease in the AMS total score [ WMD = −2.96 (−4.21, −1.71), p < .00001] and the psychological [ WMD = −0.89 (−1.41, −0.37), p = .0008], somatic [ WMD = −0.89 (−1.41, −0.37), p = .0008] and sexual [ WMD = −1.29 (−1.75, −0.83), p < .00001] subscale score.