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Outcomes of intracytoplasmic sperm injection in oligozoospermic men with Y chromosome AZF b or AZF c microdeletions
Author(s) -
Liu X.Y.,
Wang R.X.,
Fu Y.,
Luo L.L.,
Guo W.,
Liu R.Z.
Publication year - 2017
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12602
Subject(s) - intracytoplasmic sperm injection , y chromosome microdeletion , andrology , gynecology , medicine , azoospermia factor , pregnancy rate , y chromosome , azoospermia , infertility , obstetrics , biology , pregnancy , genetics , gene
Summary We investigated whether the presence of Y chromosome azoospermia factor ( AZF ) microdeletions impacts upon the outcomes of intracytoplasmic sperm injection ( ICSI ) using fresh ejaculated spermatozoa. Sixteen oligozoospermia patients with Y chromosome AZF b or AZF c microdeletions and undergoing ICSI cycles between March 2013 and November 2014 were studied. Twenty‐six infertile men with normal Y chromosomes and also undergoing IVF / ICSI in the same time period were used as controls. A retrospective case–control study approach was used. Among the 16 cases, 12 (75%, 12/16) had deletions of AZF c markers ( sY 152, sY 254 and sY 255), one (6.25%, 1/16) had a deletion of sY 152, and two (12.5%, 2/16) had deletions of sY 152, sY 254, sY 255 and sY 157. AZF b microdeletions were found in one patient (6.25%, 1/16). There were no significant differences between groups for cleaved embryo rate, high‐grade embryo rate, blastocyst formation rate, embryo implantation rate, clinical pregnancy rate and delivery rate. The clinical outcomes of ICSI for oligozoospermic patients with Y chromosome AZF microdeletion are comparable to those of infertile patients with normal Y chromosomes. Our findings indicate that ICSI should be offered to patients with an AZF c deletion and that oligozoospermia patients with AZF b microdeletions are likely to father children.