Association of single nucleotide polymorphisms in   UBR 2  gene with idiopathic aspermia or oligospermia in Sichuan, China | Zendy

Ma T. J. | Zendy; Zhang X. J. | Zendy; Ding X. P. | Zendy; Chen H. H. | Zendy; Zhang Y. W. | Zendy; Ding M. | Zendy

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Association of single nucleotide polymorphisms in UBR 2 gene with idiopathic aspermia or oligospermia in Sichuan, China

Author(s) -

Ma T. J.,

Zhang X. J.,

Ding X. P.,

Chen H. H.,

Zhang Y. W.,

Ding M.

Publication year - 2016

Publication title -

andrologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 59

eISSN - 1439-0272

pISSN - 0303-4569

DOI - 10.1111/and.12569

Subject(s) - oligospermia , odds ratio , single nucleotide polymorphism , confidence interval , genotype , gynecology , medicine , biology , case control study , male infertility , genetics , gene , infertility , pregnancy

Summary The associations between three single nucleotide polymorphisms ( SNP s; rs3749897, rs16895863 and rs373341) of UBR 2 gene and idiopathic aspermia or oligospermia were investigated in this study by a case–control experiment with 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia. The time‐of‐flight mass spectrometry (Sequenom Mass ARRAY ® system) was used in this study. A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [ OR ]: 2.764; 95% CI : 95% confidence interval [ CI ]: 1.171–6.525; P = 0.017), which could indicate that the combined AT ‐ TC ‐ CC genotype in the UBR 2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.

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