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Association of single nucleotide polymorphisms in UBR 2 gene with idiopathic aspermia or oligospermia in Sichuan, China
Author(s) -
Ma T. J.,
Zhang X. J.,
Ding X. P.,
Chen H. H.,
Zhang Y. W.,
Ding M.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12569
Subject(s) - oligospermia , odds ratio , single nucleotide polymorphism , confidence interval , genotype , gynecology , medicine , biology , case control study , male infertility , genetics , gene , infertility , pregnancy
Summary The associations between three single nucleotide polymorphisms ( SNP s; rs3749897, rs16895863 and rs373341) of UBR 2 gene and idiopathic aspermia or oligospermia were investigated in this study by a case–control experiment with 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia. The time‐of‐flight mass spectrometry (Sequenom Mass ARRAY ® system) was used in this study. A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [ OR ]: 2.764; 95% CI : 95% confidence interval [ CI ]: 1.171–6.525; P = 0.017), which could indicate that the combined AT ‐ TC ‐ CC genotype in the UBR 2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.