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Effects of continuous long‐term testosterone therapy ( TT h) on anthropometric, endocrine and metabolic parameters for up to 10 years in 115 hypogonadal elderly men: real‐life experience from an observational registry study
Author(s) -
Yassin A. A.,
Nettleship J.,
Almehmadi Y.,
Salman M.,
Saad F.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12514
Subject(s) - medicine , testosterone (patch) , body mass index , anthropometry , blood pressure , endocrinology , waist , metabolic syndrome , insulin resistance , prospective cohort study , cholesterol , obesity
Summary Subnormal levels of testosterone are associated with significant negative health consequences, with higher risks of all‐cause and cardiovascular mortality. The numbers of studies reporting on the benefits of normalisation of testosterone is increasing but longer‐term data on (elderly) men receiving testosterone treatment are almost nonexistent. In this single‐centre, cumulative, prospective, registry study, 115 hypogonadal men (mean age 59.05 years) received injections with testosterone undecanoate in 12‐week intervals for up to 10 years. Waist circumference, body weight and mean BMI dropped progressively with statistical significance versus previous year for 7 years and, respectively, 8 years for weight and body mass index. Similarly, fasting glucose displayed a significant decrease after the first year continuing to decrease thereafter. A decline in HbA 1c , from 6.4% to 5.6% (mean <6%), was observed from year 2 on, together with a decrease in the ratio of triglycerides:high‐density lipoprotein ( HDL ), a surrogate marker of insulin resistance, with an increase in HDL levels. The total cholesterol: HDL ratio and non‐ HDL cholesterol declined significantly. A decrease was also observed in systolic and diastolic blood pressure, with a decrease in levels of the inflammation marker C‐reactive protein. No major adverse cardiovascular events were observed throughout the study.