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Effect of levofloxacin treatment on semen hyperviscosity in chronic bacterial prostatitis patients
Author(s) -
Vicari L. O.,
Castiglione R.,
Salemi M.,
Vicari B. O.,
Mazzarino M. C.,
Vicari E.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12456
Subject(s) - chronic bacterial prostatitis , prostatitis , levofloxacin , semen , medicine , sperm motility , andrology , sperm , antibiotics , gastroenterology , motility , infertility , immunology , biology , prostate , microbiology and biotechnology , pregnancy , genetics , cancer
Summary Changes in seminal fluid viscosity ( SFV ), reactive oxygen species ( ROS ) production, cytokines and seminal leucocyte concentration related to microbiological outcome in patients with chronic bacterial prostatitis ( CBP ) were studied. One hundred and ten infertile patients with CBP (positive sperm culture ≥10 5 colony‐forming units [ CFU ] ml −1 , pathogens or Chlamydia in expressed prostatic secretions) were treated with levofloxacin 500 mg daily for 14 consecutive days per month for 3 months. In case of bacterial prostatitis, two conditions were examined: responders, eradication of 0 to <10 3 CFU ml −1 ( n = 78) and poor responders, >10 3 to <10 5 CFU ml −1 ( n = 32). Compared with poor responders, responders showed a significant increase of sperm progressive motility and a significant decrease in seminal leucocyte count, SFV , liquefaction time, ROS production (in all fractions and conditions), seminal tumour necrosis factor‐α and interleukin 6. None of these variables showed significant differences compared with a control group of 37 fertile men. On the other hand, the poor responders showed significant changes in these variables compared with matched pretreatment values. In patients with CBP , antibiotic therapy alone leads to eradication in ≈71%, with improvement of sperm progressive motility, SFV and the framework of prooxidative factors. However, in the remaining ≈29% with poor antibiotic responsiveness, a deterioration of all variables is observed.