Premium
Effect of androgen deprivation on the expression of aquaporins in rat prostate and seminal vesicles
Author(s) -
Tian J. C.,
Xia J. Y.,
Jiang J.,
Jiang R.,
He Y. Z.,
Lin H.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12442
Subject(s) - prostate , seminal vesicle , testosterone (patch) , endocrinology , castration , vesicle , medicine , orchiectomy , androgen , andrology , chemistry , hormone , biochemistry , cancer , membrane
Summary The aim of this study was to investigate the level of secretions of prostate and seminal vesicles and its association with the expression of AQP 0, 1, 4, 5, 6 and 8 in castrated rats. Eight‐week‐old male Sprague‐Dawley ( SD ) rats ( n = 18) were randomly divided into control group, castrated rats group and castrated followed testosterone replacement group. Four weeks after surgery, the secretions and expression of AQP 0, 1, 4, 5, 6 and 8 of prostate and seminal vesicles were determined. Serum testosterone was significantly lower in castrated groups than in control and testosterone replacement groups ( P < 0.05). The level of prostate and seminal vesicle secretions and the expressions of AQP 0, 1, 4, 5, 6 and 8 in prostate and seminal vesicles were significantly lower in castrated group than in control and castrated followed testosterone replacement groups ( P < 0.05). The decreased prostatic and seminal vesicle secretions in castrated rats may be related to the decrease in AQP 0, 1, 4, 5, 6 and 8 in prostatic tissue and seminal vesicles.