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Oxidative stress in benign prostate hyperplasia
Author(s) -
Zabaiou N.,
Mabed D.,
Lobaccaro J. M.,
Lahouel M.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12420
Subject(s) - oxidative stress , glutathione peroxidase , hyperplasia , malondialdehyde , glutathione , superoxide dismutase , medicine , prostate , prostate specific antigen , antioxidant , endocrinology , glutathione reductase , catalase , chemistry , biochemistry , enzyme , cancer
Summary To assess the status of oxidative stress in benign prostate hyperplasia, a very common disease in older men which constitutes a public health problem in Jijel, prostate tissues were obtained by transvesical adenomectomy from 10 men with benign prostate hyperplasia. We measured the cytosolic levels of malondialdehyde ( MDA ) and glutathione ( GSH ) and cytosolic enzyme activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S‐transferase. The development of benign prostate hyperplasia is accompanied by impaired oxidative status by increasing levels of MDA , depletion of GSH concentrations and a decrease in the activity of all the antioxidant enzymes studied. These results have allowed us to understand a part of the aetiology of benign prostate hyperplasia related to oxidative stress.