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Different outcomes after intracytoplasmic sperm injection without oocyte activation in two patients with different types of globozoospermia
Author(s) -
Zhang Z.Q.,
Long S.G.,
Huang Z.H.,
Xin C.L.,
Wu Q.F.
Publication year - 2016
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12409
Subject(s) - intracytoplasmic sperm injection , oocyte activation , oocyte , fertilisation , andrology , human fertilization , pregnancy rate , embryo transfer , pregnancy , ovarian hyperstimulation syndrome , controlled ovarian hyperstimulation , medicine , gynecology , in vitro fertilisation , embryo , embryogenesis , biology , anatomy , reproductive technology , microbiology and biotechnology , genetics
Summary Different outcomes after intracytoplasmic sperm injection ( ICSI ) without oocyte activation in two patients with different types of round‐headed spermatozoa (globozoospermia) are reported. After controlled ovarian hyperstimulation and oocyte pick‐up, retrieved oocytes were underwent ICSI without oocyte activation and a 33.33% (4/12) fertilisation rate was obtained in the first case, whereas an abnormal fertilisation was achieved in the second case. The transfer of two grade II embryos in the first couple resulted in clinical pregnancy with a healthy livebirth. It was concluded that the main problem of cases with globozoospermia was a low fertilisation rate or failure fertilisation, and even though ICSI and artificial oocyte activation have been employed to increase this rate, it is not necessarily needed to achieve a pregnancy.