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Preventive effect of P ueraria mirifica on testosterone‐induced prostatic hyperplasia in S prague D awley rats
Author(s) -
Masrudin S. S.,
Mohamad J.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12396
Subject(s) - pueraria , hyperplasia , testosterone (patch) , medicine , endocrinology , traditional medicine , alternative medicine , pathology
Summary Pueraria mirifica (PM) extract contains phytoestrogen daidzein and genistein. In this study, we investigated the protective effect of PM extract, daidzein and genistein on a testosterone‐induced prostatic hyperplasia in rats. Testosterone was administered at 3 mg kg −1 to rats followed by the PM extract, daidzein and genistein for a period of 30 days with finasteride as positive control. The testosterone level was increased, indicating inhibition of 5α‐reductase converting testosterone to dihydrotestosterone. This was confirmed by prostate‐specific antigen level that significantly decreased when treated with PM extract, daidzein and genistein. The PM extract, daidzein and genistein reduced the increase in the prostate/body weight ratio in testosterone‐induced rats. This gives indication that PM extract, daidzein and genistein possessed protective activity for the treatment of benign prostatic hyperplasia. The analysis of histoarchitechture of the prostate has also shown that there was a significant improvement in prostatic cells of the testosterone‐induced rats when treated with PM extract, daidzein and genistein.