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Lipoprotein‐associated phospholipase A 2 levels are associated with erectile dysfunction in patients without known coronary artery disease
Author(s) -
Otunctemur A.,
Sahin S.,
Ozbek E.,
Cekmen M.,
İnal A.,
Tulubas F.,
Dursun M.,
Besiroglu H.,
Koklu I.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12322
Subject(s) - erectile dysfunction , lipoprotein associated phospholipase a2 , medicine , pathogenesis , endothelial dysfunction , coronary artery disease , logistic regression , lipoprotein , gastroenterology , phospholipase a2 , disease , endocrinology , cardiology , cholesterol , biology , enzyme , biochemistry
Summary Endothelial dysfunction and microvascular damage play a crucial role in the pathogenesis of erectile dysfunction ( ED ). L p‐ PLA 2 is a calcium‐independent member of the phospholipase A 2 family and hydrolyses oxidised phospholipids on low‐density lipoprotein ( LDL ) particles that plays a pivotal role in ox‐ LDL ‐induced endothelial dysfunction. The purpose of the current study was to determine the association between L p‐ PLA 2 levels and ED in patients without known coronary artery disease ( CAD ). All patients were evaluated for ED and divided into two groups: 88 patients suffering from ED for >1 year were enrolled as an experimental group and 88 patients without ED were enrolled as a control group in this study. Diagnosis of ED was based on the I nternational I ndex of E rectile F unction S core‐5. Levels of L p‐ PLA 2 were measured in serum by colorimetric assay. The relationship between L p‐ PLA 2 levels and ED in patients was evaluated statistically. The mean age of patients with ED group was 59.4 ± 11.32 and 55.8 ± 9.67 in the control group. Plasma L p‐ PLA 2 levels were significantly higher in ED than in the control group (220.3 ± 66.90 and 174.8 ± 58.83 pg ml −1 , respectively, P < 0.001). The L p‐ PLA 2 levels were negatively correlated with score of ED ( r = −0.482, P < 0.05). In logistic regression analysis, enhanced plasma L p‐ PLA 2 levels result in approximately 1.2‐fold increase in ED [1.22 (1.25–2.76)]. In this study, serum L p‐ PLA 2 levels were found to be associated with endothelial dysfunction predictive of ED . Serum L p‐ PLA 2 level appears to be a specific predictor of ED , and it may be used in early prediction of ED in the male population.