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Cisplatin‐induced testicular dysfunction and its amelioration by L aunaea taraxacifolia leaf extract
Author(s) -
Adejuwon S. A.,
FemiAkinlosotu O. M.,
Omirinde J. O.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12302
Subject(s) - cisplatin , sperm , superoxide dismutase , glutathione , lipid peroxidation , catalase , antioxidant , saline , endocrinology , pharmacology , chemistry , medicine , andrology , biology , enzyme , biochemistry , chemotherapy
Summary This study investigates the ameliorative potential of L aunea taraxacifolia ( LT ) aqueous leaf extract on cisplatin‐induced testicular dysfunction in W istar rats. Thirty rats were randomly divided into six groups (A–F) of 5 rats each: Group A which served as control received water; Group B was intraperitoneally (ip) injected 10 mg kg −1 body wt cisplatin on day 21; Groups C and D were given 100 and 400 mg of LT via oral administration, respectively, for 21 days while Groups E and F received similar treatment as Groups C and D, respectively, and then exposed to ip administration of 10 mg kg −1 body weight cisplatin on the 21st day. Exclusively, Cisplatin‐exposed Group B rats showed reduced sperm characteristics and increased sperm morphological abnormalities; distorted histological architecture of seminiferous tubules; significantly increased lipid peroxidation ( LPO ) and decreased activities of superoxide dismutase ( SOD ), catalase ( CAT ) and glutathione ( GSH )levels in the testes. These parameters in LT alone treated Groups C and D were not markedly different compared with the control group. The rats with the combined treatment in Groups E and F showed significantly improved sperm parameters, testicular histo‐architecture and antioxidant enzymatic activities. Conclusively, aqueous extract of L . taraxacifolia has protective potential against cisplatin damage.