Cisplatin‐induced testicular dysfunction and its amelioration by L aunaea taraxacifolia leaf extract

Summary This study investigates the ameliorative potential of L aunea taraxacifolia ( LT ) aqueous leaf extract on cisplatin‐induced testicular dysfunction in W istar rats. Thirty rats were randomly divided into six groups (A–F) of 5 rats each: Group A which served as control received water; Group B was intraperitoneally (ip) injected 10 mg kg −1 body wt cisplatin on day 21; Groups C and D were given 100 and 400 mg of LT via oral administration, respectively, for 21 days while Groups E and F received similar treatment as Groups C and D, respectively, and then exposed to ip administration of 10 mg kg −1 body weight cisplatin on the 21st day. Exclusively, Cisplatin‐exposed Group B rats showed reduced sperm characteristics and increased sperm morphological abnormalities; distorted histological architecture of seminiferous tubules; significantly increased lipid peroxidation ( LPO ) and decreased activities of superoxide dismutase ( SOD ), catalase ( CAT ) and glutathione ( GSH )levels in the testes. These parameters in LT alone treated Groups C and D were not markedly different compared with the control group. The rats with the combined treatment in Groups E and F showed significantly improved sperm parameters, testicular histo‐architecture and antioxidant enzymatic activities. Conclusively, aqueous extract of L . taraxacifolia has protective potential against cisplatin damage.