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Exploration of the association between chronic periodontal disease and erectile dysfunction from a population‐based view point
Author(s) -
Tsao C.W.,
Liu C.Y.,
Cha T.L.,
Wu S.T.,
Chen S.C.,
Hsu C.Y.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12294
Subject(s) - erectile dysfunction , medicine , pathological , disease , population , chronic periodontitis , periodontitis , environmental health
Summary Several cross‐sectional studies have indicated an association between chronic periodontal disease ( CPD ) and cardiovascular disease and metabolic syndrome. Erectile dysfunction ( ED ) also shares pathological mechanisms with these diseases. Using a nationwide population‐based data set, we examined the association between ED and CPD and assessed the effect of dental extraction ( DE ) on ED prevalence in different aged CPD populations in Taiwan. We identified 5105 patients with ED and randomly selected 10 210 patients as controls. Of these patients, 2617 (17.09%) were diagnosed with CPD according to the index data: 1196 (23.43%) in the ED group and 1421 (13.92%) in the control group. After adjusting for comorbid factors, patients with ED were more likely to have been diagnosed with prior CPD than controls ( OR = 1.79, 95% CI = 1.64–1.96, P < 0.001). Moreover, the association was much stronger in the populations aged less than 30 years ( OR = 2.13, 95% CI = 1.23–3.70, P < 0.001) and more than 59 years ( OR = 2.27, 95% CI = 1.99–2.59, P < 0.001). Dental extraction seems to attenuate damage to the penile endothelial beds caused by CPD ‐related inflammation and overcame the process of ED in the middle‐aged and older populations.