Premium
Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase‐5 inhibitors in the treatment of premature ejaculation
Author(s) -
Polat E. C.,
Ozbek E.,
Otunctemur A.,
Ozcan L.,
Simsek A.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12289
Subject(s) - premature ejaculation , tadalafil , paroxetine , discontinuation , medicine , ejaculation , sexual intercourse , erectile dysfunction , combination therapy , urology , serotonin , psychology , population , receptor , environmental health , psychoanalysis
Summary We aimed to evaluate the effectiveness of paroxetine and tadalafil combination in the treatment of premature ejaculation ( PE ). A total of 150 primary (lifelong) PE patients were randomly distributed into three groups of 50 patients each. Group 1 received 20 mg paroxetine every day for 1 month, Group 2 received 20 mg tadalafil on demand 2 h before intercourse, and Group 3 received paroxetine and tadalafil on demand 2 h before intercourse. Intravaginal ejaculatory latency times ( IELT ) scores were evaluated at baseline, at the end of the first month of therapy and 1 month after discontinuation of the treatment, while International Index of Erectile Function ( IIEF ) questionnaire scores were evaluated both prior to and after the treatment. At the end of the first month of therapy, IELT scores were compared with the basal values and statistically significant changes were detected (60.6 ± 30.2–117.3 ± 67.3, 68.5 ± 21.4–110.2 ± 37.3, 71.56 ± 40.23–175.2 ± 60.2)( P < 0.01). IELT scores after discontinuation of treatment were found to be close to the baseline IELT scores ( P > 0.05). IIEF scores were evaluated both prior to and after the treatment, and no statistically significant difference was detected ( P > 0.05). It is concluded that utilisation of selective serotonin reuptake inhibitors ( SSRI ) and phosphodiesterase‐5 inhibitors ( PDE 5i) combination before intercourse seems to provide significantly longer ejaculatory latency times as compared with SSRI alone for a long time in patients with PE .