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Dose‐dependent effects of ethanol extract of S alvia haematodes W all roots on reproductive function and copulatory behaviour in male rats
Author(s) -
Bansode F. W.,
Rajendran S. M.,
Singh R. K.
Publication year - 2015
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12255
Subject(s) - epididymis , spermatogenesis , sperm , ejaculation , andrology , biology , medicine , endocrinology
Summary This study was aimed to investigate the dose‐dependent effects of S alvia haematodes W all roots ( SHW ) extract on male reproductive function and copulatory behaviour in rats. Sexually mature males were assigned to four groups: control and treated (5, 50 and 300 mg kg −1 day −1 for 30 days). At the end of treatment regimes, the reproductive activity viz. body/organ weights, testicular spermatogenesis, daily sperm production rate ( DSP ) and epididymal sperm counts, and sexual behaviour including mounting latency ( ML ), mounting frequency ( MF ), intromission latency ( IL ), intromission frequency ( IF ), ejaculation latency ( EL ), post‐ejaculatory interval ( PEI ) and penile reflexes ( PE ) were assessed. Results showed significant increase in body weight (at 300 mg kg −1 ), testis/epididymis weights (at 50 and 300 mg kg −1 ), testicular spermatids, DSP , tubular diameter and epididymal sperm counts (at 50 and 300 mg kg −1 doses) in treated compared with control rats. It also produced dose‐dependant changes in sexual behaviour. The 5 mg kg −1 dose of extract increased MF and PE , whereas 50 and 300 kg −1 doses caused significant increase in MF , IF , PE , EL (but less than sildenafil citrate treatment), hit rate and seminal plug weight. It is concluded that SHW extract enhances anabolic activity, testicular function and sexual behavioural performance in a dose‐dependant manner.