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Impaired emotional state, quality of life and cognitive functions in young hypogonadal men
Author(s) -
Lašaitė L.,
Čeponis J.,
Preikša R. T.,
Žilaitienė B.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12199
Subject(s) - cognition , quality of life (healthcare) , mood , medicine , psychology , young adult , wechsler adult intelligence scale , depression (economics) , psychomotor learning , clinical psychology , psychiatry , economics , macroeconomics , nursing
Summary The study aimed to analyse emotional state, quality of life and cognitive functions in young hypogonadal men. Thirty‐four males with hypogonadism (age 29.1 ± 10.5 years) and 34 age‐matched healthy males (age 30.5 ± 11.0 years) were recruited. Their emotional state was evaluated by Profile of Mood States, quality of life – by WHO Brief Quality of Life Questionnaire – and cognitive functioning – by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. It was found that young men with hypogonadism had higher depression‐dejection (13.1 ± 8.8 versus 7.4 ± 5.9, P = 0.003), fatigue‐inertia (10.0 ± 5.8 versus 7.0 ± 4.9, P = 0.030), confusion‐bewilderment (5.1 ± 4.6 versus 2.3 ± 3.1, P = 0.004) and lower vigour‐activity (14.3 ± 5.1 versus 17.7 ± 4.3, P = 0.008) levels than age‐ and sex‐matched controls. Quality of life psychological (13.1 ± 2.8 versus 15.1 ± 1.9, P = 0.005) and social (13.6 ± 2.4 versus 15.7 ± 2.0, P < 0.001) domains were significantly worse in men with hypogonadism than in controls. Cognitive functions were significantly worse ( P < 0.001) in men with hypogonadism than in controls, showing worse executive function, attention, visual scanning abilities and psychomotor speed. A significant correlation was found between testosterone concentration and quality of life psychological domain. Cognitive functioning scores were significantly related with FT 4 concentration. It is concluded that young hypogonadal patients have impaired emotional state and quality of life, but the most severe impairment was found in cognitive functioning.