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Association of the gonadotrophin‐regulated testicular RNA helicase gene polymorphism with human male infertility
Author(s) -
Jaiswal D.,
Trivedi S.,
Agrawal N. K.,
Singh K.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12185
Subject(s) - male infertility , infertility , rna helicase a , gene , allele , biology , rna splicing , genetics , single nucleotide polymorphism , transcription (linguistics) , intron , messenger rna , genotype , helicase , rna , pregnancy , linguistics , philosophy
Summary Gonadotrophin‐regulated testicular RNA helicase ( GRTH ) plays an important role in RNA functions including nuclear transcription, pre‐m RNA splicing and it regulates the translation of specific genes required for the progression of spermatogenesis. In this study, we analysed the association of GRTH gene IVS 6+55 G / T and c.852 C / T polymorphisms with human male infertility. The study showed c.852 T allele was associated with an increased risk of male infertility ( OR : 3.16, P = 0.008), whereas IVS 6+55 G / T allele conferred no risk. In Indian population, this is the first report on association of GRTH gene SNP polymorphism and male infertility and it underscores the significance of GRTH genotypes in modulating the risk of male infertility.