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Seminal androgens, oestradiol and progesterone in oligoasthenoteratozoospermic men with varicocele
Author(s) -
Zalata A.,
ElMogy M.,
AbdelKhabir A.,
ElBayoumy Y.,
ElBaz M.,
Mostafa T.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12145
Subject(s) - sperm , testosterone (patch) , varicocele , semen , medicine , endocrinology , sperm motility , androstenedione , andrology , male infertility , biology , infertility , hormone , androgen , pregnancy , genetics
Summary This study aimed to assess seminal androgens, oestradiol, progesterone levels in oligoasthenoteratozoospermic ( OAT ) men with varicocele (Vx). In all, 154 men with matched age and body mass index were investigated that were divided into healthy fertile controls ( n = 35), OAT men with Vx ( n = 55), OAT men without Vx ( n = 64). They were subjected to assessment of semen parameters, seminal levels of testosterone (T), androstenedione (A), 5α‐androstane‐3 α,17 β‐diol (3 α‐diol), oestradiol (E 2 ), 17‐hydroxyprogesterone (17‐ OHP ) and progesterone (P). Seminal levels of T and A were significantly decreased where seminal levels of 3 α‐diol, E 2 , 17‐ OHP , P were significantly higher in OAT men with/without Vx compared with fertile controls. Sperm count, sperm motility and sperm normal forms percentage demonstrated significant positive correlation with seminal T and A and significant negative correlation with seminal 3 α‐diol, E 2 , P. It is concluded that in fertile men, seminal T and A are significantly increased and seminal 3 α‐diol, E 2 , 17‐ OHP , P are significantly decreased compared with infertile OAT men with/without Vx. Association of Vx demonstrated a nonsignificant influence on these hormonal levels in OAT cases. Sperm count, sperm motility and sperm normal forms demonstrated significant positive correlation with seminal T, A and significant negative correlation with seminal 3 α‐diol, E 2 , P.