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Prevalence of carcinoma in situ in testicular biopsies of infertile I ranian men
Author(s) -
Soltanghoraee H.,
Pourkeramati F.,
Khoddami M.,
Amirjannati N.,
Akhondi M. M.,
Soltani A.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12139
Subject(s) - carcinoma in situ , medicine , infertility , carcinoma , gynecology , male infertility , immunohistochemistry , pathology , pregnancy , biology , genetics
Summary Almost all testicular germ cell tumours are proved to originate from carcinoma in situ cells. Infertility is one of the factors that increase the risk of carcinoma in situ . The reported prevalence for carcinoma in situ from different parts of the world is 0–3.7% in infertile men. This retrospective study was performed to determine the prevalence of carcinoma in situ in Iranian infertile men. We reviewed the testicular biopsies of 1153 infertile men at the pathology department of A vicenna I nfertility C enter. One hundred and fifty‐one cases were suspicious of having carcinoma in situ . Immunohistochemical marker for placental alkaline phosphatase was employed to confirm the diagnosis of carcinoma in situ . Positive results were detected in 7 (0.6%) of 1153 cases (95% CI 0.24%–1.24%), 6 (0.94%) of which (95% CI 0.34%–2.04%) were under the age of 35 years (636 patients were in this age group). This study is the first study in I ran determining the prevalence of carcinoma in situ among the infertile I ranian men; the result is in the range of reports from other countries.