Premium
Successful use of aromatase inhibitor letrozole in NOA with an elevated FSH level: a case report
Author(s) -
Zhao D.,
Pan L.,
Zhang F.,
Pan F.,
Ma J.,
Zhang X.,
Liu Y.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12122
Subject(s) - letrozole , aromatase , spermatogenesis , aromatase inhibitor , testosterone (patch) , oligospermia , medicine , endocrinology , male infertility , andrology , infertility , gynecology , biology , pregnancy , breast cancer , cancer , genetics
Summary Aromatase inhibitors inhibit the conversion of testosterone to oestrogens and could reduce serum oestradiol concentrations. Letrozole is one of aromatase inhibitors frequently used in treatment of men with oligospermia. We present the case of an infertile man with small testes and an elevated FSH level, which was diagnosed as NOA , hypospermatogenesis proven by testicular biopsy. After taking letrozole for 3 months, semen analyses by computer‐aided sperm analysis present that this man had normal spermatogenesis. This is the first case report of the activation of spermatogenesis, in man who was NOA with elevated FSH level, resulting from the use of the one of aromatase inhibitors.