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Assessment of sperm hyperactivated motility and acrosome reaction can discriminate the use of spermatozoa for conventional in vitro fertilisation or intracytoplasmic sperm injection: Preliminary results
Author(s) -
Wiser A.,
Sachar S.,
Ghetler Y.,
Shulman A.,
Breitbart H.
Publication year - 2014
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12068
Subject(s) - intracytoplasmic sperm injection , fertilisation , andrology , acrosome reaction , sperm , in vitro fertilisation , insemination , semen , sperm motility , male infertility , semen analysis , pregnancy rate , human fertilization , infertility , artificial insemination , medicine , acrosome , gynecology , biology , cryopreservation , embryo , reproductive technology , anatomy , pregnancy , genetics
Summary Basic semen analysis is insufficient for determining the fertility potential. The aim of this study was to determine if hyperactivated motility ( HAM ) and acrosome reaction ( AR ) can be useful tests for evaluating semen quality during male infertility evaluations and to help the clinician decide whether regular insemination or intracytoplasmic sperm injection ( ICSI ) is preferable during in vitro fertilisation. A prospective study was conducted. Patients with normal sperm according to World Health Organization guidelines who underwent IVF treatment and planned regular insemination were asked to participate. A portion of sperm sample was evaluated for HAM and AR on day of ovum pick up. In HAM assessment, 93.3% of patients with increased HAM had a high fertilisation rate compared with 64% in the group without increased HAM ( P  = 0.059). For the AR evaluation, 91.7% of samples with a low rate of spontaneous AR had a high fertilisation rate compared with 39.3% in the group with a high rate of spontaneous AR ( P  =   0.004).

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