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A randomised controlled trial of fibrinogen concentrate during scoliosis surgery
Author(s) -
Chen W.,
Shen J.,
Zhang Y.,
Hu A.,
Liang J.,
Ma L.,
Yu X.,
Huang Y.
Publication year - 2020
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.15124
Subject(s) - medicine , fibrinogen , scoliosis , placebo , saline , surgery , blood transfusion , anesthesia , alternative medicine , pathology
Summary Bleeding and blood transfusion are common after scoliosis surgery. Fibrinogen is essential for blood clot formation and depletes quickly during haemorrhage. We randomly allocated 102 children 12–18 years old having surgery for idiopathic scoliosis, 51 to intra‐operative fibrinogen concentrate 30 mg.kg −1 (maximum 2 g) and 51 to saline placebo. Fibrinogen reduced peri‐operative blood loss by a median (95%CI) volume of 155 (5–320) ml, from a median (IQR [range]) of 1035 (818–1420 [400–3030]) ml to 885 (755–1155 [270–2645]) ml, p = 0.04. Seven and four children received allogeneic red blood cell transfusion after fibrinogen and placebo, respectively, p = 0.34. There were no side‐effects.