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Comparison of reversal with neostigmine of low‐dose rocuronium vs. reversal with sugammadex of high‐dose rocuronium for a short procedure
Author(s) -
Choi E. S.,
Oh A. Y.,
Koo B. W.,
Hwang J. W.,
Han J. W.,
Seo K. S.,
Ahn S. H.,
Jeong W. J.
Publication year - 2017
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.13894
Subject(s) - rocuronium , sugammadex , medicine , neostigmine , anesthesia , laryngoscopy , intubation , sore throat , tracheal intubation , neuromuscular blockade , surgery
Summary Some short procedures require deep neuromuscular blockade, which needs to be reversed at the end of the procedure. Forty‐four patients undergoing elective laryngeal micro‐surgery were randomly allocated into two groups: rocuronium 0.45 mg.kg −1 with neostigmine (50 μg.kg −1 with glycopyrrolate 10 μg.kg −1 ) reversal (moderate block group) vs. rocuronium 0.90 mg.kg −1 with sugammadex (4 mg.kg −1 ) reversal (deep block group). The primary outcome was the intubating conditions during laryngoscopy secondary outcomes included recovery of neuromuscular block; conditions for tracheal intubation; satisfaction score as determined by the surgeon; onset of neuromuscular block; and postoperative sore throat. The onset of neuromuscular block was more rapid, and intubation conditions and ease of intra‐operative laryngoscopy were more favourable, and the satisfaction score was lower in the moderate block group compared with the deep block group. No difference was found in the incidence of postoperative sore throat. In laryngeal micro‐surgery, the use of rocuronium 0.9 mg.kg −1 with sugammadex for reversal was associated with better surgical conditions and a shorter recovery time than rocuronium 0.45 mg.kg −1 with neostigmine.