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Determination of the median effective dose ( ED 50 ) of spinal chloroprocaine in labour analgesia
Author(s) -
Coppens M.,
Anssens S.,
Parashchanka A.,
Roelens K.,
Deschepper E.,
De Hert S.,
Wouters P. F.
Publication year - 2017
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.13808
Subject(s) - medicine , anesthesia , sufentanil , saline , visual analogue scale , surgery
Summary The primary goal of this study was to determine the median effective dose ( ED 50 ) of spinal chloroprocaine for labour analgesia. Thirty‐eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up–down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal‐epidural, which was then supplemented with an epidural dose of 7.5 μg sufentanil in 7 ml saline. Effective analgesia was defined as a score ≤ 10 mm within 15 min on a 100‐mm visual analogue pain scale. Using the isotonic regression estimator method, the ED 50 of chloroprocaine for the spinal component of a combined spinal‐epidural for labour was calculated to be median (95% CI ) 12.0 (9.3–17.0) mg.