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The association between pre‐operative variables, including blood pressure, and postoperative kidney function
Author(s) -
Kendale S. M.,
Lapis P. N.,
Melhem S. M.,
Blitz J. D.
Publication year - 2016
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.13632
Subject(s) - medicine , renal function , quartile , blood pressure , acute kidney injury , mean arterial pressure , odds ratio , surgery , anesthesia , urology , cardiology , heart rate , confidence interval
Summary We used multivariate analyses to assess the association of pre‐operative variables with kidney function in 41,523 adults after scheduled surgery in a single large academic hospital. Eight variables were independently associated with a reduction in postoperative estimated glomerular filtration rate: pre‐operative renal function; age; ASA physical status; cardiac failure; anaemia; cancer; type of surgery; and the lowest quartile of pre‐operative mean arterial blood pressure (< 71 mmHg). The estimated glomerular filtration rate fell by a mean (95% CI ) of 2.7 (0.04–5.40) ml.min −1 .1.73 m −2 for patients with a pre‐operative mean arterial pressure < 71 mmHg, p = 0.047. The same variables and male sex were associated with postoperative acute kidney injury. The odds ratio (95% CI ) for acute postoperative kidney injury was 1.9 (1.2–2.9) for patients with a pre‐operative mean arterial blood pressure < 71 mmHg, p = 0.005.