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A systematic review of capnography for sedation
Author(s) -
Conway A.,
Douglas C.,
Sutherland J. R.
Publication year - 2016
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.13378
Subject(s) - medicine , capnography , relative risk , meta analysis , colonoscopy , sedation , subgroup analysis , confidence interval , anesthesia , colorectal cancer , cancer
Summary We included six trials with 2524 participants. Capnography reduced hypoxaemic episodes, relative risk (95% CI ) 0.71 (0.56–0.91), p = 0.02, but the quality of evidence was poor due to high risks of performance bias and detection bias and substantial statistical heterogeneity. The reduction in hypoxaemic episodes was statistically homogeneous in the subgroup of three trials of 1823 adults sedated for colonoscopy, relative risk (95% CI ) 0.59 (0.48–0.73), p < 0.001, although the risks of performance and detection biases were high. There was no evidence that capnography affected other outcomes, including assisted ventilation, relative risk (95% CI ) 0.58 (0.26–1.27), p = 0.17.