Premium
A systematic review of peri‐operative melatonin
Author(s) -
Andersen L. P. H.,
Werner M. U.,
Rosenberg J.,
Gögenur I.
Publication year - 2014
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.12717
Subject(s) - melatonin , medicine , anxiety , placebo , anesthesia , perioperative , sleep quality , sleep (system call) , oxidative stress , psychiatry , insomnia , alternative medicine , pathology , computer science , operating system
Summary We systematically reviewed randomised controlled trials of peri‐operative melatonin. We included 24 studies of 1794 participants that reported eight peri‐operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre‐operative anxiety score by 0.88 (0.44–1.33) and postoperative pain score by 1.06 (0.23–1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I 2 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.