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Genetic variation and cognitive dysfunction one year after cardiac surgery
Author(s) -
Stewart A.,
Katznelson R.,
Kraeva N.,
Carroll J.,
Pickworth T.,
Rao V.,
Djaiani G.
Publication year - 2013
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.12170
Subject(s) - medicine , postoperative cognitive dysfunction , cognition , apolipoprotein e , apolipoprotein b , allele , neuropsychology , effects of sleep deprivation on cognitive performance , cardiology , bioinformatics , surgery , genetics , psychiatry , gene , disease , cholesterol , biology
Summary Various studies have implicated a potential association between candidate gene polymorphisms and postoperative cognitive dysfunction, yet corroborative studies are lacking. We investigated the variants in genes encoding platelet glycoprotein‐IIIa and apolipoprotein‐E and their relationship with postoperative cognitive dysfunction one year after cardiac surgery. A total of 155 patients were studied; neuropsychological testing demonstrated cognitive dysfunction in 31 (20%) patients at one‐year follow‐up. No differences were detected with respect to baseline characteristics, pre‐operative variables and surgical data between the patients with and without cognitive dysfunction. The Pl A2 ‐allele of the platelet glycoprotein‐IIIa gene was present in 13 (42%) and 25 (20%) patients with and without cognitive dysfunction, respectively, p = 0.012. The apolipoprotein E‐ε4 allele was present in 9 (29%) and 24 (19%) patients with and without cognitive dysfunction, respectively, p = 0.24. Both the Pl A2 and apolipoprotein‐ε4 alleles were present together in 6 (19%) and 5 (4%) patients with and without cognitive dysfunction, respectively, p = 0.003. Validation of these findings is required in age‐adjusted non‐surgical controls.