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The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy
Author(s) -
Sasaki Mari,
Schwab Clarissa,
Ramirez Garcia Alejandro,
Li Qing,
Ferstl Ruth,
Bersuch Eugen,
Akdis Cezmi A.,
Lauener Roger,
Frei Remo,
Roduit Caroline
Publication year - 2022
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.15440
Subject(s) - ruminococcus , biology , akkermansia muciniphila , lachnospiraceae , atopic dermatitis , firmicutes , butyrate , bacteroidetes , fusobacteria , gut flora , feces , physiology , microbiology and biotechnology , immunology , food science , fermentation , bacteria , genetics , 16s ribosomal rna
Background Impaired microbial development and decreased levels of short‐chain fatty acids, particularly butyrate, is suggested to have a role in the development of atopic dermatitis (AD). Methods Faecal microbiota composition, abundance of selected bacterial groups and fermentation metabolites were compared at 90, 180 and 360 days of life between 27 children who developed AD by age one (AD group), and 39 controls (non‐AD group) among the CARE (Childhood AlleRgy, nutrition and Environment) study cohort. Results Diversity within the Firmicutes and Bacteroidetes phyla in the faecal microbiota was lower in the AD group compared with the non‐AD group. Longitudinal analysis showed multiple amplicon sequence variants (ASV) within the same bacterial family to be differentially abundant. Namely, Ruminococcus bromii , a keystone primary starch degrader, and Akkermansia muciniphila , a mucin‐utilizer, had lower abundance among the AD group. Children with AD were less likely to have high levels of faecal butyrate at 360 days compared with those without AD (11.5% vs 34.2%). At 360 days, children with high abundance of R. bromii had higher level of butyrate as well as lower proportion of children with AD compared to children with low abundance of R. bromii (11.1–12.5% vs 44.4–52.5%), which was independent of the abundance of the major butyrate producers. Conclusion Our results suggested that R. bromii and other primary degraders might play an important role in the differences in microbial cross‐feeding and metabolite formation between children with and without AD, which may influence the risk of developing the disease.