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Hypersensitivity reactions to biologicals: An EAACI position paper
Author(s) -
Bavbek Sevim,
Pagani Mauro,
AlvarezCuesta Emilio,
Castells Mariana,
Dursun Adile Berna,
Hamadi Sahar,
MadrigalBurgaleta Ricardo,
SanchezSanchez Soledad,
Vultaggio Alessandra
Publication year - 2022
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14984
Subject(s) - medicine , position paper , intensive care medicine , immunology , pathology
Biologicals are crucial targeted therapeutic agents in oncological, immunological, and inflammatory diseases, and their use in clinical practice is broadening. In recent years, the spread of Personalized Precision Medicine has facilitated a proliferation of new treatment options, especially biologicals. Consequently, biologicals are now among the drugs that most frequently cause hypersensitivity reactions (HSRs). Patients can develop HSRs to these agents during the first‐lifetime exposure or after repeated exposure, and these HSRs can be potentially life‐threatening or limit therapeutic options. Despite the relatively high prevalence, the underlying mechanisms of these HSRs remain obscure, and the optimal management pathways are still a matter of discussion. In this Position Paper, the authors will provide evidence‐based recommendations for diagnosing and managing HSRs to biologicals. Additionally, the document defines unmet needs as an opportunity to shape future research.