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Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives
Author(s) -
Sampath Vanitha,
Rabinowitz Grace,
Shah Mihir,
Jain Surabhi,
Diamant Zuzana,
Jesenak Milos,
Rabin Ronald,
Vieths Stefan,
Agache Ioana,
Akdis Mübeccel,
Barber Domingo,
Breiteneder Heimo,
Chinthrajah Sharon,
Chivato Tomas,
Collins William,
Eiwegger Thomas,
Fast Katharine,
Fokkens Wytske,
O'Hehir Robyn E.,
Ollert Markus,
O'Mahony Liam,
Palomares Oscar,
Pfaar Oliver,
Riggioni Carmen,
Shamji Mohamed H,
Sokolowska Milena,
Jose Torres Maria,
TraidlHoffmann Claudia,
Zelm Menno,
Wang De Yun,
Zhang Luo,
Akdis Cezmi A.,
Nadeau Kari C.
Publication year - 2021
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14840
Subject(s) - medicine , pandemic , vaccination , intensive care medicine , covid-19 , adverse effect , immunology , public health , disease , environmental health , infectious disease (medical specialty) , nursing , pathology
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID‐19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post‐authorization and post‐marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.