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Extract and molecular‐based early infant sensitization and associated factors—A PreventADALL study
Author(s) -
Tedner Sandra G.,
Söderhäll Cilla,
Konradsen Jon R.,
Bains Karen E. S.,
Borres Magnus P.,
Carlsen KaiHåkon,
Carlsen Karin C. L.,
Färdig Martin,
Gerdin Sabina W.,
Gudmundsdóttir Hrefna K.,
Haugen Guttorm,
Hedlin Gunilla,
Jonassen Christine M.,
Kreyberg Ina,
Mägi CarolineAleksi O.,
Nordhagen Live S.,
Rehbinder Eva M.,
Rudi Knut,
Skjerven Håvard O.,
Staff Anne C.,
Vettukattil Riyas,
Hage Marianne,
Nordlund Björn,
Asarnoj Anna
Publication year - 2021
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14805
Subject(s) - sensitization , medicine , immunoglobulin e , food allergens , allergen , food allergy , allergy , intoxicative inhalant , odds ratio , immunology , oral food challenge , food protein , gliadin , gluten , food science , toxicology , biology , antibody , pathology
Background More knowledge about sensitization patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. Objective We aimed to determine the prevalence and patterns of allergic sensitization at 3 months of age, and explore possible associated factors. Methods From the Scandinavian antenatally recruited PreventADALL mother–child cohort, we included 1110 3‐month infants with available serum. Sensitization was defined as s‐IgE of ≥0.1 kU A /L by Phadiatop Infant ® (ThermoFisher Scientific) including birch, cat, grass, dog, milk, egg, peanut and wheat. Further ImmunoCAP analyses to ovomucoid, casein, Ara h 1‐3, omega‐5‐gliadin were performed in food extract s‐IgE‐positive children. Maternal sensitization was defined as s‐IgE ≥ 0.35 kU A /L to Phadiatop ® (inhalant allergen mix) and/or Fx5 (food allergen mix) at 18‐week pregnancy. Results Overall 79 (7.3%) infants had specific sensitization, many with low s‐IgE‐levels (IQR 0.16–0.81 kU A /L), with 78 being sensitized to food extract allergens; 41 to egg, 27 to milk, 10 to peanut, and 25 to wheat. A total of 62/78 were further analysed, 18 (29%) had s‐IgE to ovomucoid, casein, Ara h 1‐3 and/or omega‐5‐gliadin. Eight infants (0.7%) were sensitized to inhalant allergens. Maternal sensitization to food allergens was associated with infant sensitization, odds ratio 3.64 (95% CI 1.53–8.68). Conclusion Already at 3 months of age, 7% were sensitized to food, mostly without detectable s‐IgE to food allergen molecules, and <1% to inhalant allergens. Maternal food sensitization was associated with infants’ sensitization.