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Management of patients with atopic dermatitis undergoing systemic therapy during COVID‐19 pandemic in Italy: Data from the DA‐COVID‐19 registry
Author(s) -
Chiricozzi Andrea,
Talamonti Marina,
De Simone Clara,
Galluzzo Marco,
Gori Niccolò,
Fabbrocini Gabriella,
Marzano Angelo Valerio,
Girolomoni Giampiero,
Offidani Annamaria,
Rossi Maria Teresa,
Bianchi Luca,
Cristaudo Antonio,
Fierro Maria Teresa,
Stingeni Luca,
Pellacani Giovanni,
Argenziano Giuseppe,
Patrizi Annalisa,
Pigatto Paolo,
Romanelli Marco,
Savoia Paola,
Rubegni Pietro,
Foti Caterina,
Milanesi Nicola,
Belloni Fortina Anna,
Bongiorno Maria Rita,
Grieco Teresa,
Di Nuzzo Sergio,
Fargnoli Maria Concetta,
Carugno Andrea,
Motolese Alberico,
Rongioletti Franco,
Amerio Paolo,
Balestri Riccardo,
Potenza Concetta,
Micali Giuseppe,
Patruno Cataldo,
Zalaudek Iris,
Lombardo Maurizio,
Feliciani Claudio,
Di Nardo Lucia,
Guarneri Fabrizio,
Peris Ketty
Publication year - 2021
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14767
Subject(s) - medicine , pandemic , atopic dermatitis , covid-19 , disease , young adult , severity of illness , pediatrics , dermatology , emergency medicine , infectious disease (medical specialty)
Abstract Background Few and small studies have described the management of immunomodulant/immunosuppressive therapies or phototherapy in atopic dermatitis (AD) patients during coronavirus disease 2019 (COVID‐19) pandemic. Methods A national registry, named DA‐COVID‐19 and involving 35 Italian dermatology units, was established in order to evaluate the impact of COVID‐19 pandemic on the management of adult AD patients treated with systemic immunomodulant/immunosuppressive medications or phototherapy. Demographic and clinical data were obtained at different timepoints by teledermatology during COVID‐19 pandemic, when regular visits were not allowed due to sanitary restrictions. Disease severity was assessed by both physician‐ and patient‐reported assessment scores evaluating itch intensity, sleep disturbances, and AD severity. Results A total of 1831 patients were included, with 1580/1831 (86.3%) continuing therapy during pandemic. Most patients were treated with dupilumab (86.1%, 1576/1831) that was interrupted in only 9.9% (156/1576) of cases, while systemic immunosuppressive compounds were more frequently withdrawn. Treatment interruption was due to decision of the patient, general practitioner, or dermatologist in 39.9% (114/286), 5.6% (16/286), and 30.1% (86/286) of cases, respectively. Fear of increased susceptibility to SARS‐CoV‐2 infection (24.8%, 71/286) was one of the main causes of interruption. Sixteen patients (0.9%) resulted positive to SARS‐CoV‐2 infection; 3 of them (0.2%) were hospitalized but no cases of COVID‐related death occurred. Conclusions Most AD patients continued systemic treatments during COVID pandemic and lockdown period, without high impact on disease control, particularly dupilumab‐treated patients.