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Overview of oral tolerance induction for prevention of food allergy—Where are we now?
Author(s) -
Krawiec Marta,
Fisher Helen R.,
Du Toit George,
Bahnson Henry T.,
Lack Gideon
Publication year - 2021
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14758
Subject(s) - food allergy , medicine , oral tolerance , intervention (counseling) , oral food challenge , weaning , population , randomized controlled trial , intensive care medicine , allergy , pediatrics , environmental health , immunology , surgery , psychiatry , immune system
Abstract Oral tolerance induction through early introduction of allergenic food has proven effective in randomized controlled trials. This new approach to weaning has been incorporated into many national and international infants’ feeding guidelines. However, there are questions that require further discussion, such as, which foods should be introduced early, should the intervention be targeted to infants at high‐risk or to the general population, and what is the ideal timing for early food introduction. This review examines the extent to which recent trials address these critical questions and highlights areas where further research is required.