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Phenotyping peach‐allergic patients sensitized to lipid transfer protein and analysing severity biomarkers
Author(s) -
Bogas Gador,
MuñozCano Rosa,
Mayorga Cristobalina,
Casas Rocio,
Bartra Joan,
Pérez Natalia,
Pascal Mariona,
Palomares Francisca,
Torres María José,
Gómez Francisca
Publication year - 2020
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14447
Subject(s) - sensitization , plant lipid transfer proteins , medicine , allergy , profilin , oral allergy syndrome , anaphylaxis , allergen , pollen , immunology , immunoglobulin e , botany , biology , biochemistry , gene , actin cytoskeleton , cytoskeleton , cell , antibody
Abstract Background Patients with peach allergy due to nsLTP sensitization constitute a heterogeneous group in terms of sensitization profile and severity. This could be due to the presence of additional allergies to pollens. The aim of this study was to analyse the clinical characteristics, sensitization profile and severity of reactions in peach‐allergic patients sensitized to nsLTP from two Mediterranean areas with different pollen exposure. Methods Patients with diagnosis of LTP allergy from the Allergy Unit of Hospital Regional Universitario de Malaga (HRUM) and Hospital Clinic de Barcelona (HCB) were prospectively included and classified into two groups; (a) LTP‐monoallergic: those that presented reaction only with peach and (b) LTP‐Allergy: those that presented reaction with peach and at least another plant‐food containing LTP. Results A total of 252 patients were included, 235 (93.2%) had LTP‐syndrome and 17 (6.8%) were LTP‐monoallergic. We found a higher percentage of anaphylaxis and delayed onset of symptoms in the LTP‐monoallergic group ( P = .02 and P = .04, respectively). Moreover, anaphylaxis was less frequent in patients with profilin sensitization ( P = .03). The comparison of patients' data from HRUM with data from HCB showed differences in sensitization to olive tree pollen and profilin ( P = .01 and P = .001, respectively). Conclusion This study was undertaken to characterize two large group of subjects from to two regions with differing exposures to pollen. We found that more than 90% of peach‐allergic patients in both populations evolved to LTP‐Allergy and showed an early onset. Profilin sensitization could be more useful as a severity biomarker than the number of nsLTP, aeroallergen sensitizations or sIgE levels. This could provide clues regarding sensitization and severity patterns that might be relevant in other geographical areas.