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EAACI Biologicals Guidelines—Recommendations for severe asthma
Author(s) -
Agache Ioana,
Akdis Cezmi A.,
Akdis Mubeccel,
Caica Giorgio Walter,
Casale Thomas,
Chivato Tomas,
Corren Jonathan,
Chu Derek K.,
Del Giacco Stefano,
Eiwegger Thomas,
Flood Breda,
Firinu Davide,
Gern James E.,
Hamelmann Eckard,
Hanania Nicola,
HernándezMartín Irene,
Knibb Rebeca,
Mäkelä Mika,
Nair Parameswaran,
O’Mahony Liam,
Papadopoulos Nikolaos G.,
Papi Alberto,
Park HaeSim,
Pérez de Llano Luis,
Pfaar Oliver,
Quirce Santiago,
Sastre Joaquin,
Shamji Mohamed,
Schwarze Jurgen,
Palomares Oscar,
Jutel Marek
Publication year - 2021
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14425
Subject(s) - medicine , asthma , intensive care medicine , disease management , health care , regimen , healthcare system , alternative medicine , family medicine , pediatrics , health management system , immunology , pathology , economics , economic growth
Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. However, there are still many issues that require further clarification. These include selection of a certain biological (as they all target overlapping disease phenotypes), the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home‐based) and its cost‐effectiveness. The EAACI Guidelines on the use of biologicals in severe asthma follow the GRADE approach in formulating recommendations for each biological and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future approaches and research priorities.