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The impact of the prostaglandin D 2 receptor 2 and its downstream effects on the pathophysiology of asthma
Author(s) -
Brightling Christopher E.,
Brusselle Guy,
Altman Pablo
Publication year - 2020
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.14001
Subject(s) - pathophysiology of asthma , immunology , pathophysiology , receptor , eosinophil , prostaglandin d2 , medicine , asthma , biology , endocrinology
Abstract Current research suggests that the prostaglandin D 2 (PGD 2 ) receptor 2 (DP 2 ) is a principal regulator in the pathophysiology of asthma, because it stimulates and amplifies the inflammatory response in this condition. The DP 2 receptor can be activated by both allergic and nonallergic stimuli, leading to several pro‐inflammatory events, including eosinophil activation and migration, release of the type 2 cytokines interleukin (IL)‐4, IL‐5 and IL‐13 from T helper 2 (Th2) cells and innate lymphoid cells type 2 (ILCs), and increased airway smooth muscle mass via recruitment of mesenchymal progenitors to the airway smooth muscle bundle. Activation of the DP 2 receptor pathway has potential downstream effects on asthma pathophysiology, including on airway epithelial cells, mucus hypersecretion, and airway remodelling, and consequently might impact asthma symptoms and exacerbations. Given the broad distribution of DP 2 receptors on immune and structural cells involved in asthma, this receptor is being explored as a novel therapeutic target.