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Medical Algorithms: Diagnosis and treatment of Hymenoptera venom allergy
Author(s) -
Sturm Gunter J.,
ArztGradwohl Lisa,
Varga Eva M.
Publication year - 2019
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.13817
Subject(s) - sting , allergy , medicine , venom , immunoglobulin e , immunotherapy , dermatology , anaphylactic reactions , anaphylaxis , immunology , quality of life (healthcare) , biology , antibody , ecology , immune system , nursing , engineering , aerospace engineering
Diagnosis of Hymenoptera venom allergy (HVA) is straightforward in the majority of patients, but can be challenging in double positive and test negative patients. Test results sometimes can be confusing as patients with high skin test reactivity and high specific IgE (sIgE) levels are not at risk for severe systemic sting reactions (SSR), and conversely, patients with weakly positive or even negative tests can experience severe SSR. Venom immunotherapy (VIT) is safe, highly effective, and recommended in patients with moderate to severe SSR and in patients with SSR confined to generalized skin symptoms if quality of life is impaired.