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The relationship between nasopharyngeal CCL 5 and microbiota on disease severity among infants with bronchiolitis
Author(s) -
Hasegawa K.,
Mansbach J. M.,
Ajami N. J.,
Petrosino J. F,
Freishtat R. J.,
Teach S. J.,
Piedra P. A.,
Camargo C. A.
Publication year - 2017
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.13160
Subject(s) - bronchiolitis , moraxella , medicine , airway , prospective cohort study , moraxella catarrhalis , asthma , cohort study , haemophilus , immunology , pediatrics , haemophilus influenzae , respiratory system , biology , microbiology and biotechnology , bacteria , anesthesia , antibiotics , genetics
Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL 5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age <1 year) hospitalized for bronchiolitis during 2011‐2014, we observed statistically significant interactions between nasopharyngeal airway CCL 5 levels and microbiota profiles with regard to the risk of both intensive care use ( P interaction =.02) and hospital length‐of‐stay ≥3 days ( P interaction =.03). Among infants with lower CCL 5 levels, the Haemophilus ‐dominant microbiota profile was associated with a higher risk of intensive care use ( OR , 3.20; 95% CI , 1.18‐8.68; P =.02) and hospital length‐of‐stay ≥3 days ( OR , 4.14; 95% CI , 2.08‐8.24; P <.001) compared to the Moraxella ‐dominant profile. Conversely, among those with higher CCL 5 levels, there were no significant associations between the microbiota profiles and these severity outcomes (all P ≥.10).