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Topical ivermectin improves allergic skin inflammation
Author(s) -
Ventre E.,
Rozières A.,
Lenief V.,
Albert F.,
Rossio P.,
Laoubi L.,
Dombrowicz D.,
Staels B.,
Ulmann L.,
Julia V.,
Vial E.,
Jomard A.,
HaciniRachinel F.,
Nicolas J.F.,
Vocanson M.
Publication year - 2017
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.13118
Subject(s) - immunology , medicine , inflammation , atopic dermatitis , cytokine , allergy , allergic inflammation , ivermectin , in vivo , biology , microbiology and biotechnology , veterinary medicine
Background Ivermectin ( IVM ) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti‐inflammatory properties. Methods Here, we investigated the activity of IVM in a murine model of atopic dermatitis ( AD ) induced by repeated exposure to the allergen Dermatophagoides farinae , and in standard cellular immunological assays. Results Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen‐specific T cells, as well as the production of inflammatory cytokines. While IVM had no major impact on the functions of dendritic cells in vivo and in vitro , IVM impaired T‐cell activation, proliferation, and cytokine production following polyclonal and antigen‐specific stimulation. Conclusion Altogether, our results show that IVM is endowed with topical anti‐inflammatory properties that could have important applications for the treatment of T‐cell‐mediated skin inflammatory diseases.