Premium
The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1
Author(s) -
Apostolovic D.,
SánchezVidaurre S.,
Waden K.,
Curin M.,
Grundström J.,
Gafvelin G.,
Cirkovic Velickovic T.,
Grönlund H.,
Thomas W. R.,
Valenta R.,
Hamsten C.,
Hage M.
Publication year - 2016
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12955
Subject(s) - lipocalin , immunoglobulin e , sensitization , immunology , epitope , medicine , population , allergen , cross reactivity , in vitro , cross reactions , chemistry , allergy , antibody , biochemistry , environmental health
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat‐sensitized Swedish patients and elucidated its allergenic activity and cross‐reactivity with the dog lipocalin Can f 1. Sixty‐five of 140 patients had IgE to rF el d 7 whereof 60 also had IgE to rC an f 1. A moderate correlation between IgE levels to rF el d 7 and rC an f 1 was found. rF el d 7 activated basophils in vitro and inhibited IgE binding to rC an f 1 in 4 of 13 patients, whereas rC an f 1 inhibited IgE binding to rF el d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross‐reactive antisera. Fel d 7 is a common allergen in a Swedish cat‐sensitized population that cross‐reacts with Can f 1, and may contribute to symptoms in cat‐ but also in dog‐allergic patients.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom