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Systematic characterization of basophil anergy
Author(s) -
Puan Kia Joo,
Andiappan Anand Kumar,
Lee Bernett,
Kumar Dilip,
Lai Tuck Siong,
Yeo Giminna,
Bercin Derya,
Starke Mireille,
Haase Doreen,
Lum Josephine,
Chew Fook Tim,
Connolly John,
Wong Siew Cheng,
Zolezzi Francesca,
Poidinger Michael,
Wang De Yun,
Rötzschke Olaf
Publication year - 2017
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12952
Subject(s) - immunology , basophil , medicine , immunoglobulin e , antibody
Background Cohort studies indicated that in certain individuals the basophils do not respond toward allergens due to a desensitization of their Fc epsilon receptor pathway. Cause and functional role as well as the implications on allergic reactions, however, are not clear yet. Methods A cross‐sectional study was carried out in the tropical urban environment of Singapore, where the allergic response is dominated by a single allergen (house dust mite; HDM ). Blood samples were collected from 476 individuals and analyzed comprehensively to correlate the functional state of their basophils with the clinical state as well as the composition of the cellular and soluble plasma components. Results Inactivation of basophils (‘basophil anergy’) was observed in about 10% of the cohort. It was associated with a downregulation of basophil Syk and an apparent reduction in the incidence of allergic rhinitis. Correlations on the cohort level suggest that it represents a transitional state to be passed through during the interconversion of responder and nonresponder state. Conclusions Basophil anergy thus seems to function as activation barrier to prevent unwanted reactions against minor allergens. It may therefore be relevant for diagnostic purposes or therapeutic interventions of allergic diseases.