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Late reactions in food‐allergic children and adolescents after double‐blind, placebo‐controlled food challenges
Author(s) -
SalehLangenberg J.,
Flokstrade Blok B. M. J.,
AlAgla N.,
Kollen B. J.,
Dubois A. E. J.
Publication year - 2016
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12923
Subject(s) - placebo , food allergy , food hypersensitivity , medicine , food allergens , double blind , allergy , environmental health , pediatrics , immunology , alternative medicine , pathology
Abstract The time during which children are observed following a double‐blind, placebo‐controlled food challenge ( DBPCFC ) varies in clinical practice. There are little data on late reactions ( LR s) following DBPCFC s. Therefore, we determined the prevalence, severity and clinical characteristics of late reactions in food‐allergic children and adolescents after DBPCFC , and ascertained which factors are associated with, and may predict, LR s. Logistic regression analyses were performed to investigate which factors were associated with LR s and to develop the association and prediction models. A total of 1142 children underwent DBPCFC s (child–test combinations). Of these 1142 child–test combinations, 400 reported LR s following the DBPCFC . LR s in food‐allergic children after DBPCFC are poorly predictable and are generally not severe. All LR s, including those on the placebo day, are more frequently reported in younger children. Children who do not experience severe immediate reactions may be safely discharged home 2 h after a DBPCFC .